• Ubiquitous Pollutant: more released annually
in USA than all other toxic gases combined
!
• Deadly Exogenous Poison
#1 cause of toxic death and poisoning in
USA
• Vital Endogenous Neurotransmitter
produced by all red-blooded animals
from breakdown of heme proteins by
HO-1,2&3
and bioactive in over 100 mammalian pathways