(c)2006 Albert Donnay
Paracelsus’ Dose Response paradigm fails to account for
exposure history and the potential for both:
a) asymptomatic habituation to high levels of exposure from chronic or
frequently repeated exposures; and
b) hypersymptomatic sensitization to very low levels of exposure
following extended withdrawal from such habituation
Individual dose response curves shift and change shape over time
depending on both recent and long-term exposure history.
Animal and human studies that do not control for their subjects’
prior exposure history may be undermined by these differences.
Occupational and public exposure limits based on the experience
of highly exposed (habituated) populations are not protective of
de-habituated and sensitized populations