uParacelsus’ Dose Response paradigm fails to account for
exposure history and the potential for
both:
ua) asymptomatic habituation to high levels of exposure from
chronic or frequently repeated
exposures; and
ub) hypersymptomatic sensitization to very low levels of
exposure following extended
withdrawal from such habituation
uIndividual dose response curves shift and change shape over
time depending on both
recent and long-term exposure history.
uAnimal and human studies that do not control for their
subjects’ prior exposure
history may be undermined by these differences.
uOccupational and public exposure limits based on the experience
of highly exposed (habituated) populations
are not protective of
de-habituated and
sensitized populations
u