uWell Recognized Non-Controversial
Exceptions:
uAt the high end of
exposure, clear that for some toxins,
increasing dose
beyond some level does not increase symptoms,
aka the threshold effect or habituation
uAt the low end,
clear that those with allergies experience symptoms at much lower doses (even trace exposures)
compared to those
without allergies, aka the atopic
response
u
uControversial exceptions:
uClear but not well
understood why some dose response curves are NOT LINEAR, but U-shaped, aka the hormetic response
uAlso not well
understood why some individuals develop
non-allergic
sensitization to very low levels of chemical(s) and other stressors that were previously well tolerated,
aka the “I can’t
party like I used to” effect, or MUSES Syndrome