(c)2006 Albert Donnay
But Edgar Allan Poe (1809-1849)
first recognized the essence of sensitization
uPoe changed from having a high tolerance for alcohol and
partying in his college years to low tolerance later in life:
u“My sensitive temperament could not stand an excitement
which was an everyday matter to my companions. ...
For some days after each excess I was invariably confined to bed.”                          EAP, letter to Dr. Joseph Snodgrass, 8/1/1841
uPoe became hypersensitive not just to alcohol but to all types of sensory stimuli (aka, Multi-Sensory Sensitivity):
u““True!—nervous—very, very dreadfully nervous I had been and am; but why will you say that I am mad? The disease had sharpened my senses—not destroyed, not dulled them. … Have I not told you that what you mistake for madness is but overacuteness of the senses?”  EAP, The Tell Tale Heart, 1843
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